Enzyme Technology

Upstream and Downstream processing

Cell line study

In vitro antimicrobial and antitubercular study

• Formulation Development & Optimization of various Novel Drug Delivery Systems including Nanoparticulate drug delivery system, Pulmonary targeted drug delivery system, Metered dose Inhaler, Vaginal Drug Delivery system.
• Pharmaceutical Pre-formulation and material characterization, Physico-chemical characterization, Polymorphism
• Solubility enhancement technologies
• Particle engineering, Crystalography
• Co-processing to improve physico-technical properties
• Solid state characterization of pharmaceuticals.
• Generation of co - crystals to improve aqueous solubility of poorly water soluble drugs
• Improved powder properties using particle engineering and co-processing of pharmaceuticals; Study of compression behaviour.
• Improving oral bioavailability of poorly water soluble using different types of nano formulations.
• Nanoparticulate drug delivery system Focus on drug targeting to cancer.
• In vitro and in vivo evaluation of conventional and new drug delivery systems.

• Development and validation of the analytical and bioanalytical method
• Extractable and leachable studies
• Determination and quantification of pesticide residues from food articles by various analytical techniques.
  
• Standardization of herbal drug formulation
• Development of nanoparticulate drug delivery system for improved dissolution and bioavailability of the poorly soluble drug
• Study, review and compare various regulatory guideline on nutraceuticals, medical device, drug substance, drug product with a view to developing various regulatory documents for submission and registration like NDA, ANDA, CTD, CAPA, Clinical and non-clinical trial, BA/BE studies, marketing authorization etc. 

Broad Area of research: Neuro & Cardiovascular pharmacology

Specific area of research:

• Screening of isolated phytoconstituent or extracts of medicinal plants on experimental diabetic stroke and Parkinson’s disease
• Effect of chemicals on diabetic complications (cardiac and renal)
• An antimalarial potential of selected phytoconstituents
• Brief procedure
• At pharmacology lab, we are interested in the screening of isolated phytoconstituent on diabetic stroke against a global/focal model of ischemia in rats and Parkinson’s disease (6-OHDA model).
• Molecules screened: solasodine, Trans cinnamic Acid, Ellagic acid, Geraniol

Major instruments available:

• Data Acquisition System (Biopac Systems Ltd)
• Stereotaxic apparatus (Stoelting Co Ltd)
• ELISA plate reader (Biotek Ltd)
• Upright microscope (Leica)
• Slide staining machine (Yorko)
• Microtome (Yorko)